Breaking the Bottlenecks in Purifying Combinatorial and Medicinal Chemistry Compounds
Purification remains a fundamental bottleneck in the synthesis of new chemical entities. As turnaround time and purity requirements have become more demanding, many chemists today rely on preparative HPLC as the method of choice over classical techniques. A number of enhancements designed to automate the process are now routine, including application of generic separation protocols and MS-controlled fraction collection. Despite these advances, speed of separation, resolution of chromatographic bands, and evaporation of collected peaks remain principal bottlenecks in the purification process.
Thermo Fisher Scientific preparative systems, using our proprietary TurboFlow® technology, break the fundamental bottlenecks in the purification of combinatorial and medicinal chemistry compounds. Our comprehensive solution, which addresses even the most challenging purification issues, quickly delivers complete DMSO depletion, higher throughput, superior resolution, online separation and recovery, and direct scale-up from analytical to preparative.
Our new preparative chromatography systems break the purification bottlenecks by delivering:
- Increased throughput
- Reduced time to purification
- Simplified scale-up
- Automated method development
For more information on our new, fully automated preparative systems, email us at info.sid.franklin@thermofisher.com.